To ensure your keyboard shortcuts work with external controllers like Stream Deck or when PlayIt Live doesn't have focus, you need to enable the "Global trigger" setting. Go to File > Settings, click on the "Keyboard" tab, and tick the "Global trigger" checkbox at the bottom of the keyboard settings section. This single setting applies to all configured shortcuts, ensuring they work even when PlayIt Live is in the background. After enabling this option, click OK to save your changes. If shortcuts still don't work, check whether another application might be intercepting the same key combinations.